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Aphthous ulcer drug reverses obesity in mice

February 14, 2013 |
A drug used to treat aphthous ulcers reversed obesity and diabetes in lab mice, according to results of a study.

Amlexanox, used in the United States to treat canker sores, was tested by researchers with the University of Michigan’s Life Science Institute for its impact on diabetes and obesity in mice, according to a university news release. Investigators treated mice with high-fat diets, but gave one group amlexanox.

The drug inhibited two genes, IKKE and TBK1, allowing for an elevated energy release through increased thermogenesis, according to the study abstract. The result was weight loss, improved insulin sensitivity and decreased steatosis in the mice treated with amlexanox.

The effectiveness of amlexanox for treating obesity and diabetes in humans, however, has yet to be studied, authors noted.

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Source:  by  Sarah Thuerk on February 11, 2013 for Dermatology Times at

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