Hyaluronidase: fix dermal filler mistakes
Non-animal, stabilized hyaluronic acid (NASHA) gels have become a very popular dermal filler material. In the past, if an error was made in filler quantity or placement, the solution was to wait for the material to reabsorb over several months. Hyaluronidase is an enzyme that catalyzes the breakdown of hyaluronic acid in the body, thereby increasing tissue permeability to fluids. Hyaluronidase may have the potential to speed resorption by breaking up the gel. To evaluate hyaluronidase’s effects on previously implanted NASHA gel, these researchers performed a two-part, prospective, randomized, sequential study.
In the first part, 12 healthy volunteers had 0.2 mL of NASHA gel injected into two sites, approximately 10 cm apart, on one forearm. One to 3 days after implantation, a blinded evaluator graded the cutaneous augmentation at both sites, and 75 units of hyaluronidase with thimerosal preservative were injected into one site and control saline into the other.
Read the full article at http://www.leadinginstanteyelift.com/blog/hyaluronidase
Source: by George J. Hruza, MD for Journal Watch Dermatology August 9, 2005 and posted January 23, 2013 at http://www.leadinginstanteyelift.com/blog/hyaluronidase
